ACS Fall 2025

Uploaded: Aug 17, 2025

SAMSON version: 8.0.0

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This is a SAMSON file where you can find structures corresponding to different pKa's and ready to render 3D structure.

Feel free to further reach out!

Bibliography:

  1. Aho, N.; Buslaev, P.; Jansen, A.; Bauer, P.; Groenhof, G.; Hess, B. Scalable Constant pH Molecular Dynamics in GROMACS. J. Chem. Theory Comput. 2022, 18 (10), 6148–6160.

  2. Oliveberg, M.; Arcus, V. L.; Fersht, A. R. pKA Values of Carboxyl Groups in the Native and Denatured States of Barnase: The pKA Values of the Denatured State Are on Average 0.4 Units Lower Than Those of Model Compounds. Biochemistry 1995, 34 (29), 9424–9433.

  3. Standfuss, J.; Terwisscha van Scheltinga, A. C.; Lamborghini, M.; Kühlbrandt, W. Mechanisms of Photoprotection and Nonphotochemical Quenching in Pea Light‐harvesting Complex at 2.5 Å Resolution. The EMBO Journal 2005, 24 (5), 919–928.

  4. Jubb, H. C.; Higueruelo, A. P.; Ochoa-Montaño, B.; Pitt, W. R.; Ascher, D. B.; Blundell, T. L. Arpeggio: A Web Server for Calculating and Visualising Interatomic Interactions in Protein Structures. Journal of Molecular Biology 2017, 429 (3), 365–371.

  5. Franco, L. F. M.; Pessoa Filho, P. de A. Mathematical Description of the Enzymatic Activity of Proteins with Ionizable Groups Exhibiting Deviations from the Henderson-Hasselbalch Equation. Appl Biochem Biotechnol 2022, 194 (3), 1221–1234.

  6. Olsson, Mats H. M.; Søndergaard, Chresten R.; Rostkowski, Michal; Jensen, Jan H. PROPKA3: consistent treatment of internal and surface residues in empirical pKa predictions. Journal of Chemical Theory and Computation 2011, 7 (2), 525–537.

Acknowledgment: This project has received funding from the European Union’s Horizon Europe research and innovation programme under the Marie Skłodowska-Curie Doctoral Network (MSCA-DN) grant agreement No 101119442 – PhotoCaM.

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